PC 2002: all centres/groups, trials/strata and treatments

Key: Green - ineligible for overview, nonstandard randomisation or otherwise excluded; Blue - data not (yet) received

101 CH {Knönagel: APR-1997 (SECOND REVISED VERSION)}

10101 86B CH/85/908/05: Entry JAN-1986 to OCT-1986 (51 patients were entered; terminated early)

1 Orchiectomy
2 Orchiectomy + Nilutamide

102 F {Navratil: APR-1997 (SECOND REVISED VERSION)}

10201 83B F/82/908/01: Entry JUL-1983 to MAR-1987 (208 patients were entered)

1 Buserelin/Orchiectomy
2 Buserelin/Orchiectomy + Nilutamide

103 F {Brisset: APR-1997 (SECOND REVISED VERSION)}

10301 83A F/82/908/03: Entry JUN-1983 to SEP-1986; 1:2 Randomisation (191 patients were entered)

1 Orchiectomy
2 Orchiectomy + Nilutamide [300mg/d or 150mg/d]

104 CDN {Béland: APR-1997 (SECOND REVISED VERSION)}

10401 84A CDN/83/908/05: Entry FEB-1984 to DEC-1986 (208 patients were entered)

1 Orchiectomy
2 Orchiectomy + Nilutamide

105 F {Namer: APR-1997 (SECOND REVISED VERSION)}

10501 84E F/84/908/01: Entry MAY-1984 to APR-1987 (151 patients were entered)

1 Orchiectomy
2 Orchiectomy + Nilutamide

106 ZA {Du Plessis: APR-1997 (SECOND REVISED VERSION)}

10601 85A ZA/85/908/02: Entry DEC-1985 to JUN-1986 (11 patients were entered; terminated early)

1 Orchiectomy
2 Orchiectomy + Nilutamide

107 FF {Janknegt: JUN-1997 (THIRD REVISED VERSION)}

10701 86A FF/86/908/01: Entry JUN-1986 to JUN-1988 (457 patients were entered)

1 Orchiectomy
2 Orchiectomy + Nilutamide

108 GHBA {Crawford: JUN-1997 (THIRD REVISED VERSION)}

10801 86C GHBA-606: Entry AUG-1986 to JUN-1988 (411 patients were entered)

1 Leuprolide
2 Leuprolide + Nilutamide

112 SPCG {: APR-1997}

11201 88B SPCG-1: Entry APR-1988 to MAR-1992 (285 patients were entered)

1 LHRH
2 LHRH + Cyproterone Acetate

201 EORTC {Collette, Robinson: AUG-2002 (THIRD REVISED VERSION)}

20101 81A EORTC 30805: Entry APR-1981 to JAN-1986 (351 patients were entered)

1 Orchiectomy
2 Orchiectomy + Cyproterone Acetate
3 Diethylstilboestrol

202 EORTC {Collette, de Voogt: AUG-2002 (THIRD REVISED VERSION)}

20201 84D EORTC 30843: Entry NOV-1984 to SEP-1989 (368 patients were entered)

1 Orchiectomy
2 Buserelin + Cyproterone Acetate x 2wk
3 Buserelin + Cyproterone Acetate continuous

204 EORTC {Collette, Denis: AUS-2002 (THIRD REVISED VERSION)}

20401 86E EORTC 30853: Entry MAR-1986 to MAY-1988 (327 patients were entered)

1 Orchiectomy
2 Goserelin + Flutamide

208 EORTC {Collette: FEB-2003 (REVISED VERSION) and APR-2007}

20801 86K EORTC 30846: Entry MAR-1986 to OCT-1998 (234 patients were entered)

1 (Orchiectomy / Goserelin + Cyproterone Acetate) deferred
2 (Orchiectomy / Goserelin + Cyproterone Acetate) immediate

20802 90C EORTC 30891: M0; Entry FEB-1990 to JAN-1999 (985 patients were entered)

1 (Orchiectomy / Buserelin + Cyproterone Acetate) immediate
2 (Orchiectomy / Buserelin + Cyproterone Acetate) deferred

210 EORTC {: APR-1997}

21001 90B EORTC 30892: Entry FEB-1990 to MAR-1996 (310 patients were entered)

1 Flutamide
2 Cyproterone Acetate

211 EORTC {Collette: AUG-2002 (THIRD REVISED VERSION)}

21101 90D EORTC 30893: Entry FEB-1990 to MAY-1995 (189 patients were entered) [PCTCG 002.110]

1 Orchiectomy
2 Orchiectomy + Mitomycin-C [15mg/d] x 42d

212 EORTC {Collette: FEB-2003 (THIRD REVISED VERSION)}

21201 87C EORTC 22863: M0; Entry MAY-1987 to OCT-1995 (415 patients were entered)

1 Pelvic Radiotherapy
2 Pelvic Radiotherapy + LHRH Analogue

291 EORTC {Collette: AUG-2002}

29101 96A EORTC 30943: Entry MAY-1996 to MAR-1998 (68 patients were entered; stopped early; no events recorded)

1 Immediate
2 Deferred

301 NCI {Crawford: APR-1997 (SECOND REVISED VERSION)}

30101 85B NCI/INT-0036: Metastatic Disease; Entry JAN-1985 to APR-1986 (617 patients were entered)

1 Leuprolide
2 Leuprolide + Flutamide

302 SWOG {: OCT-2000 (REVISED VERSION)}

30201 82A SWOG 8219: Entry OCT-1982 to OCT-1986 (143 patients were entered) [PCTCG 003.020]

1 Orchiectomy / Diethylstilboestrol
2 (Orchiectomy / Diethylstilboestrol) + ((Doxorubicin [30mg/d] × 21d + Cyclophosphamide [650mg/d] x 21d) / (Doxorubicin [20mg/d] × 21d + Cyclophosphamide [500mg/d] x 21d) for high risk patients)

303 NCI {: APR-1997}

30301 88G NCI/INT-0105: Metastatic Disease; Entry 1988 ff. (1385 patients were entered)

1 Orchiectomy
2 Orchiectomy + Flutamide

401 DAPROCA {Iversen: APR-1997 (THIRD REVISED VERSION)}

40101 86F DAPROCA: Entry JUN-1986 to NOV-1987 (262 patients were entered)

1 Orchiectomy
2 Goserelin + Flutamide

402 DAPROCA {: OCT-2000}

40201 90G DAPROCA-9002: Entry SEP-1990 to DEC-1993 (129 patients were entered) [PCTCG 004.020]

1 Control
3 Estramustine Phosphate [560mg/d]

501 {Fourcade: APR-1997 (SECOND REVISED VERSION)}

50101 86G 118,630/1507: Entry OCT-1986 to DEC-1988 (245 patients were entered)

1 Goserelin
2 Goserelin + Flutamide

502 {Di Silverio: APR-1997 (THIRD REVISED VERSION)}

50201 84B 118,630/1502: Entry NOV-1984 to OCT-1988 (195 patients were entered; entry ages missing)

1 Goserelin
2 Goserelin + Cyproterone Acetate

503 {Di Silverio: APR-1997 (THIRD REVISED VERSION)}

50301 84C 118,630/1503: Entry OCT-1984 to MAY-1988 (133 patients were entered; entry ages missing)

1 Goserelin
2 Goserelin + Cyproterone Acetate

504 IPCSG {Lunglmayr, Tyrrell: JUN-1997 (FOURTH REVISED VERSION)}

50401 86D 118,630/1509/IPCSG: Entry JAN-1986 to OCT-1987 (586 patients were entered)

1 Goserelin + Flutamide
2 Goserelin

505 WPSG {Senge: JUN-1997 (FOURTH REVISED VERSION)}

50501 85C 118,630/1511/WPSG: Entry SEP-1985 to FEB-1988 (110 patients were entered)

1 Orchiectomy/Goserelin
2 Orchiectomy/Goserelin + Flutamide

517 Zeneca {: FEB-2004 (REVISED VERSION)}

51701 95A EPC 23 (USA): Entry AUG-1995 to AUG-1997 (3292 patients were entered)

1 Bicalutamide immediate
2 Bicalutamide deferred

51702 95B EPC 24 (Europe and Others): Entry SEP-1995 to JUL-1998 (3603 patients were entered)

1 Bicalutamide immediate
2 Bicalutamide deferred

51703 95C EPC 25 (Scandinavia): Entry OCT-1995 to JUL-1998 (1218 patients were entered)

1 Bicalutamide immediate
2 Bicalutamide deferred

801 PONCAP {Boccardo: JUN-1997 (THIRD REVISED VERSION)}

80101 87A PONCAP: Entry JUL-1987 to JAN-1991 (319 patients were entered)

1 Goserelin
2 Goserelin + Flutamide

901 BPCRGT {Gingell: MAY-1997}

90101 86J BPCRGT/SCH-262: Metastatic Disease; Entry MAY-1986 to JAN-1989 (517 patients were entered)

1 Cyproterone Acetate
2 Goserelin
3 Goserelin + Cyproterone Acetate

991 SCH-Plough {Deleare: MAY-1992}

99101 SCH-Plough: Entry ?; 222 patients were entered (not received; superseded by 120101)

1 Orchiectomy
2 Orchiectomy + Flutamide

992 SWOG {Eisenberger: MAY-1992}

99201 88A SWOG-8894/INT-0105: Entry 1988 ff. (not received; 'reject')

1 Orchiectomy
2 Orchiectomy + Flutamide

1001 M.R.C. {: FEB-2003 (SECOND REVISED VERSION)}

100101 78D MRC PR01: T0-1; Entry MAY-1978 to JUN-1983 (72 patients were entered)

1 Radiotherapy immediate
2 Radiotherapy deferred

1002 M.R.C. {: FEB-2003 (SECOND REVISED VERSION)}

100201 80A MRC PR02: T2-4 M0; Entry JUN-1980 to MAR-1985 (277 patients were entered)

1 Radiotherapy
2 Orchiectomy
3 Orchiectomy + Radiotherapy

1003 M.R.C. {: FEB-2003 (THIRD REVISED VERSION)}

100301 85D MRC PR03: Advanced Localised and Asymptomatic Metastatic; Entry JAN-1985 to DEC-1993 (938 patients were entered)

1 (Orchiectomy / Goserelin) immediate
2 (Orchiectomy / Goserelin) deferred

1140 DESG {: OCT-2000}

114011 88H DESG 1: Entry DEC-1988 to JUL-1991 (419 patients were entered) [PCTCG 114.010]

1 Orchiectomy
3 Orchiectomy + Estramustine Phosphate [840mg/d] × 1m then Estramustine Phosphate [560mg/d]

1180 GOUP {: OCT-2000}

118011 90E GOUP 1: Entry JUN-1990 to MAY-1993 (63 patients were entered) [PCTCG 118.010]

1 Goserelin
2 Goserelin + Mitomycin-C [14mg/d] x 42d

1190 ASCO {: APR-2001}

119011 90H ASCO-1: Entry AUG-1990 to APR-1994 (161 patients were entered) [PCTCG 119.010]

1 Prednisone
2 Prednisone + Mitozantrone [12mg/d] × 21d

1200 Nagoya Japan {: OCT-2000}

120011 90F Nagoya 1: Entry MAY-1990 to OCT-1992 (141 patients were entered) [PCTCG 120.010]

1 Orchiectomy + Diethylstilboestrol
2 Orchiectomy + Diethylstilboestrol + (Uracil + Tegafur) [400mg/d]

1201 SCH-Plough {: DEC-1997}

120101 86L M85713: Stage D2; Entry ?1986 ff. (330 patients were entered; no date, age or death cause information)

1 Orchiectomy
2 Orchiectomy + Flutamide

120102 86L Delaere part of M85713: Entry JAN-1986 to JAN-1987 (24 patients were entered; contained in 120101)

1 Orchiectomy
2 Orchiectomy + Flutamide

1202 {Raghavan: APR-1997 (REVISED VERSION)}

120201 86H M85712: Metastatic Disease; Entry FEB-1986 to MAY-1988 (223 patients were entered; entry ages missing)

1 Orchiectomy
2 Orchiectomy + Flutamide

1220 KPCRG {: OCT-2000}

122011 91A KPCRG-1: Entry 1991 ff. (47 patients were entered; not received) [PCTCG 122.010]

1 Goserelin Acetate depot
2 Goserelin Acetate depot + Cyclophosphamide [1000mg/d] x 28d

1230 CALGB {: OCT-2000}

123011 92A CALGB-9182: Entry OCT-1992 to SEP-1995 (242 patients were entered) [PCTCG 123.010]

1 Hydrocortisone
2 Hydrocortisone + Mitozantrone [14mg/d] x 21d

1240 SIG {: SEP-2001}

124011 94A SIG-1: Entry FEB-1994 to DEC-1996 (460 patients were entered; 2 missing)

1 Hydrocortisone
2 Hydrocortisone + Suramin

1290 Hokkaido {: SEP-2001}

129011 91B Hokkaido-1: Entry JAN-1991 to JUL-1993 (46 patients were entered) [PCTCG 129.010]

1 Orchiectomy
3 Orchiectomy + Estramustine Phosphate [560mg/d]
4 Orchiectomy + Etoposide [25mg/14d]

1301 Modena {Ferrari: JUN-1997 (SECOND REVISED VERSION)}

130101 87B Modena: Entry JAN-1987 to MAR-1992 (122 patients were entered)

1 Buserelin
2 Buserelin + Flutamide

1401 {: APR-1997 (REVISED VERSION)}

140101 89A Varese: Entry DEC-1989 to JUL-1991 (277 patients were entered; old data in situ pro temp.)

1 LHRH
2 LHRH + Flutamide

1501 Paris, France {Le Duc: JUN-1992}

150101 Nilutamide: Entry ? (47 patients were entered; not received)

1 Orchiectomy
2 Orchiectomy + Nilutamide

1702 RPMS {:}

170201 RPMS-2: Entry ? (30 patients were entered; not received)

1 Orchiectomy
2 Orchiectomy + Cyproterone Acetate

1908 RTOG {: JUN-2002}

190801 87H RTOG 8610: Entry JUN-1987 to MAY-1991 (471 patients were entered)

1 Radiotherapy + Hormonal Treatment
2 Radiotherapy

1909 RTOG {: FEB-2003 (SECOND REVISED VERSION)}

190901 87E RTOG 8531: Entry APR-1987 to APR-1992 (977 patients were entered)

1 Radiotherapy + Goserelin immediate
2 Radiotherapy + Goserelin on relapse

2401 Graz {: OCT-2000 (REVISED VERSION)}

240101 88C Graz 1: Entry MAR-1988 to JAN-1991 (143 patients were entered) [PCTCG 024.010]

1 Orchiectomy + Flutamide
2 Orchiectomy + Flutamide + 4-Epi-Doxorubicin [25mg/d] x 7d

2603 NPCP {: OCT-2000 (THIRD REVISED VERSION)}

260301 78B NPCP-900: Staging Lymph Node Dissection; Entry MAY-1978 to SEP-1985 (184 patients were entered) [PCTCG 026.030]

1 Prostatectomy
2 Prostatectomy + Cyclophosphamide [1000mg/d] x 21d
3 Prostatectomy + Estramustine Phosphate [600/d]

2604 NPCP {: OCT-2000 (THIRD REVISED VERSION)}

260401 78C NPCP-1000: Staging Lymph Node Dissection; Entry JUN-1978 to AUG-1985 (253 patients were entered) [PCTCG 026.040]

1 Radiotherapy
2 Radiotherapy + Cyclophosphamide [1000mg/d] x 21d
3 Radiotherapy + Estramustine Phosphate [600/d]

2610 NPCP {: OCT-2000}

261001 76C NPCP-500: Entry 1976 ff. (197 patients were entered; not received) [PCTCG 026.100]

1 Orchiectomy / Diethylstilboestrol
2 Diethylstilboestrol + Cyclophosphamide [1000mg/d] x 21d

2611 NPCP {: OCT-2000 (REVISED VERSION)}

261101 76B NPCP-600: Entry 1976 ff. (188 patients were entered; not received) [PCTCG 026.110]

1 Diethylstilboestrol
2 Diethylstilboestrol + Cyclophosphamide [1000mg/d] x 21d
3 Diethylstilboestrol + Estramustine Phosphate [600/d]

2616 NPCP {: OCT-2000}

261601 80B NPCP-1300: Entry 1980 ff. (217 patients were entered; not received) [PCTCG 026.160]

1 Orchiectomy / Diethylstilboestrol
2 Diethylstilboestrol + 5-Fluoro-Uracil [350mg/d] x 7d + Cyclophosphamide [1000mg/d] x 21d

2702 BUOS {: NOV-2001 (REVISED VERSION}

270201 88D BUOS 0: Entry MAY-1988 to JAN-1992 (152 patients were entered; 6 treatment allocations missing) [PCTCG 027.020]

1 Orchiectomy
2 Orchiectomy + Mitomycin-C [15mg/d] x 42d

2901 Gunma, Japan {: OCT-2000}

290101 87D Gunma 1: Entry JAN-1987 to OCT-1990 (146 patients were entered) [PCTCG 029.010]

1 LHRH Inhibitor
2 LHRH Inhibitor + (Uracil + Ftorafur) [600mg/d]
4 (unknown)

3002 SPCG {: APR-1997}

300201 84F SPCG-2: Entry SEP-1984 to MAR-1989 (222 patients were entered; incomplete data)

1 Orchiectomy
2 Orchiectomy + Cyproterone Acetate

3102 {:}

310201 Offenbach-2: Entry ? (222 patients were entered; not received; probably duplication of 300201)

1 LHRH
2 LHRH + Cyproterone Acetate

3301 Helsingborg {: JUN-2002 (THIRD REVISED VERSION)}

330101 78A1 Helsingborg-1 (Part I): M0; Entry OCT-1978 to FEB-1983 (243 patients were entered) [PCTCG 033.010]

1 Polyestradiol Phosphate + Ethinyloestradiol
2 Estramustine Phosphate [560mg/d]
3 Control

330102 78A2 Helsingborg-1 (Part II): M0; Entry MAR-1983 to OCT-1984 (42 patients were entered) [PCTCG 033.010]

1 Estramustine Phosphate [560mg/d]
2 Control
3 Polyestradiol Phosphate

330103 78A Helsingborg-1 (Subset): M0; Entry OCT-1978 to OCT-1984 (285 patients were entered; superseded by 330101-330102) [PCTCG 033.010]

1 Control
3 Estramustine Phosphate [560mg/d]
4 Polyestradiol Phosphate + Ethinyloestradiol
5 Polyestradiol Phosphate

5301 Dresden {: FEB-2003}

530101 82B Dresden 1: Entry 1982 ff. (86 patients were entered into Groups 1 and 2; 85 into Groups 1 and 3; not received) [PCTCG 053.010]

1 Orchiectomy + Ethinyloestradiol x 7d
2 Orchiectomy + (Vincristine/Vinblastine + Cyclophosphamide) then (Cyclophosphamide + Methotrexate) + Prednisolone
3 Orchiectomy + (Vincristine/Vinblastine + Cyclophosphamide) then (Cyclophosphamide + Methotrexate) + Prednisolone + Ethinyloestradiol x 7d

530102 89C Dresden 2: M0; Entry NOV-1989 to FEB-1996 (309 patients were entered)

1 Prostatectomy + Flutamide
2 Prostatectomy

5402 Miami {: OCT-2000}

540201 87F Miami-2: Entry 1987 ff. (57 patients were entered; not received) [PCTCG 054.020]

1 Prednisone
2 Prednisone + Doxorubicin [20mg/d] x 7d

5802 ECOG {: FEB-2003 (REVISED VERSION)}

580201 88F ECOG EST-3886: D1; Entry MAR-1988 to MAR-1993 (98 patients were entered; closed because of slow accrual)

1 Prostatectomy + Orchiectomy/Goserelin
2 Prostatectomy

6101 {:}

610101 Louis-1: Entry ? (36 patients were entered; not received)

1 LHRH
2 LHRH + Nilutamide

7201 WGH {:}

720101 90A WGH-1: Entry JAN-1990 ff. (20 patients were entered; not received)

1 Orchiectomy
2 Orchiectomy + Flutamide

7801 Hamburg, Germany {:}

780101 68A Hamburg-1: Entry JAN-1968 ff. (80 patients were entered; not received)

1 Orchiectomy
2 Orchiectomy + Cyproterone Acetate

7802 Hamburg, Germany {:}

780201 Hamburg-2: Entry ? (40 patients were entered; not received)

1 Orchiectomy
2 Orchiectomy + Cyproterone Acetate

7901 APCSG {: JUN-1997}

790101 APCSG 1: Entry 1988 ff. (117 patients were entered; not received)

1 Orchiectomy + Flutamide
2 Orchiectomy + Flutamide + 4-Epi-Doxorubicin

8601 Aker {:}

860101 76A Aker 1: Entry JAN-1976 ff. (22 patients were entered; not received; limited treatment duration)

1 Orchiectomy
2 Orchiectomy + Cyproterone Acetate x 6wk

9201 Texas, U.S.A. {: MAY-1997}

920101 67B Texas 1: Stage C; Entry 1967 ff. (82 patients were entered; not received; contained in another multi-centre study)

1 Radiotherapy + Diethylstilboestrol [5mg]
2 Radiotherapy

9901 VACURG {: MAY-1997 (REVISED VERSION)}

990101 60A VACURG-1-I,II: Entry MAR-1960 to MAR-1967 (299 patients were entered)

1 Prostatectomy
2 Prostatectomy + Diethylstilboestrol [5mg]

9902 VACURG {: MAY-1997 (REVISED VERSION)}

990201 60B1 VACURG-1-III,IV (5-way): Entry MAR-1960 to AUG-1962 (555 patients were entered)

1 Control
2 Diethylstilboestrol [5mg]
3 Orchiectomy
4 Orchiectomy
5 Orchiectomy + Diethylstilboestrol [5mg]

990202 60B2 VACURG-1-III,IV (4-way): Entry SEP-1962 to JUL-1967 (1459 patients were entered)

1 Control
2 Diethylstilboestrol [5mg]
3 Orchiectomy
4 Orchiectomy + Diethylstilboestrol [5mg]

9904 VACURG {: MAY-1997 (REVISED VERSION)}

990401 67A VACURG-2-III,IV: Entry APR-1967 to JUN-1969 (506 patients were entered)

1 Control
2 Diethylstilboestrol [0·2mg]
3 Diethylstilboestrol [1mg]
4 Diethylstilboestrol [5mg]

9907 VACURG {: MAY-1997 (REVISED VERSION)}

990701 69A VACURG-3 Phase 2: Ineligible for Prostatectomy; Entry JUN-1969 to APR-1975 (298 patients were entered)

1 Control
2 Diethylstilboestrol [1mg]

9909 SCS {: AUG-2002}

990901 86M SCS-1: M0; Entry 1986 ff. (91 patients were entered; not received)

1 Radiotherapy + Orchiectomy
2 Radiotherapy

9910 SAKK {Dietrich: FEB-2003 (REVISED VERSION)}

991001 88E SAKK 08-88: Entry FEB-1988 to FEB-1992 (197 patients were entered)

1 Orchiectomy immediate
2 Orchiectomy deferred

[End of document, updated to 29 June 2007]

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